en Treatment stategies with herbal or others Treatment stategies with herbal or others پژوهشي Original research papers <div style="text-align: justify;">Today, nanotechnology is considered as a priority and strategic technology for all countries due to its wide range of applications. The present study was performed to evaluate the effects of various levels of dried <em>Aloe vera </em>extract nanoparticles on some hematological parameters, liver enzymes and immune responses of Siberian sturgeon (<em>Acipencer</em> <em>baerii</em>). Three hundred sixty <em>Acipenser baerii</em> (with mean weight of 10.95 &plusmn; 0.04 g), were randomly divided into three treatment groups including 0.5%, 1% and 1.5% of nanoparticles of dried <em>Aloe vera </em>extract and one control group (without any additive), each in three replicates, stored in twelve tanks of 500-liter fiberglass with 350 liters water. Water physicochemical parameters were recorded daily. Nanoparticles&nbsp;of dried <em>A. vera</em> extract in a ratio of 0.5%, 1%, and 1.5% were added to the treatment groups diet for 2 months. At the end of the first and second months of rearing, the necessary samplings for hematology and serology studies were done.&nbsp;The results of this study showed that the amounts of RBC, Hb, Hct, MCV, WBC, lysozyme, ACH₅₀and IgM were significantly different in the treatment groups compared with the control group at the end of the study (<em>p<0.05</em>). There were no significant differences in liver enzymes including ALT, AST and ALP between treatments and control groups (<em>p>0.05</em>). In conclusion the results have shown that use of nanoparticles of dried <em>A. vera</em> extract had the impact of immune function booster and the usage of this nanoparticle mainly at the level of 1% in the diet can be used as a safety stimulant for Siberian sturgeon. <span dir="RTL"></span></div> A. vera, Nanoparticles, Hematological parameters, Immune indices, Siberian sturgeon 56 69 http://ijaah.ir/browse.php?a_code=A-10-281-1&slc_lang=en&sid=1 S Bazari Moghaddam soheilbm274@gmail.com 10031947532846002741 10031947532846002741 Yes International Sturgeon Research Institute, Iranian Fisheries Science Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Rasht, Iran M Sharif Rohani mostafasharif@yahoo.com 10031947532846002742 10031947532846002742 No Iranian Fisheries Science Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Tehran, Iran M Haghighi masoud126@yahoo.com 10031947532846002743 10031947532846002743 No Cold-water Fishes Research Center, Iranian Fisheries Science Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Tonekabon, Iran