en Treatment stategies with herbal or others Treatment stategies with herbal or others پژوهشي Original research papers <div style="text-align: justify;">Administration of human anesthesia drugs in fish is mainly because of their high efficacy and availability as well as low price. In this study anesthetic effects of Ketamine and Acepromazine (0, 15 and 30 mg L^-1) was evaluated in Shirbot (<em>Tor grypus</em>). Acepromazine concentrations prepared in 10 L containers in triplicates, then serial descending concentration of ketamine (for effective dose 20-400 mg L^-1&nbsp;and for lethal dose 320-900 mg L^-1) were added to tank. Twelve fish were added to each container. Results analyzed with probit software and EC₁₀, EC₅₀ and EC₉₀ as well as LC₁₀, LC₅₀and LC₉₀ of drugs in five minutes were measured. Results showed that no significant difference was seen in anesthesia efficacy, time of anesthesia induction and recovery time among groups (P>0.05), but lethal effects of Ketamine decreased significantly in Ketamin along with 15 mg L^-1 Acepromazine (P<0.05).&nbsp;Then it can be concluded that Acepromazine increased the safety of Ketamine in <em>Tor grypus </em>at low doses<strong>.&nbsp;</strong></div> Ketamine, Acepromazine, Tor grypus, Anesthesia 12 21 http://ijaah.ir/browse.php?a_code=A-10-148-2&slc_lang=en&sid=1 M Alishahi alishahim@scu.ac.ir 10031947532846002331 10031947532846002331 Yes Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran A. A Heidari bakhtiyar.heidari@gmail.com 10031947532846002332 10031947532846002332 No Department of Clinical Sciences, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran A Gholamhosseini Amingholamhosseini@shirazu.ac.ir 10031947532846002333 10031947532846002333 No Department of Clinical Sciences, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran H Najafzadeh Iran h.najafzadeh@mubabol.ac.ir 10031947532846002334 10031947532846002334 No Cellular and Molecular Biology Research Center Babol University of Medical Sciences, Babol, Mazandaran ,Iran